Industry needs, patent expirations of ligand design and market dynamics have accelerated the development and availability of many protein affinity resins. Technology providers must consider a range of design parameters such as resin backbone, bead size, pore size, surface chemistry modification, ligand construct and how they relate to performance criteria such as DBC, life time, caustic stability, and column packing among others. JSR’s approach to designing Amsphere A3™ affinity resin will be discussed. The trade-offs between resin design and resin performance will be illustrated through a case study.
Masayoshi Nagaya
Technical Product Manager, Separations Science Group , JSR Life Sciences
Dr. Peter Schwarz has worked with Donaldson for 10 years and is the Research & Development Manager for the global Process Filtration Division. He studied chemistry at the University Saarbruecken and got his Ph.D. with Columbia University in the City of New York/USA. During that time he won several awards like the Young Chemist Award by the Association of German Chemists or the scholarship by the State of Saarland. Based on his former position as Head of QAU he’s familiar with various quality systems like GLP etc. At Donaldson he is responsible for the liquid, steam and sterile air product portfolio.
- Understand the rationale behind the design of a Protein A resin
- Understand the relationships of bead design, ligand design and surface modifications on resin performance
- Review a case study comparing 4 mAbs and 4 commercial resin types of commercial resins
- Review mAb process productivity analysis of Ampshere A3
- Vice President
- Director
- Senior scientist
- Clinical manufacturing
- Process development
- Process sciences
- Manufacturing sciences
