Industry needs, patent expirations of ligand design and market dynamics have accelerated the development and availability of many protein affinity resins. Technology providers must consider a range of design parameters such as resin backbone, bead size, pore size, surface chemistry modification, ligand construct and how they relate to performance criteria such as DBC, life time, caustic stability, and column packing among others.
JSR’s approach to designing Amsphere A3™ affinity resin will be discussed. The balance between resin design and resin performance will be illustrated through a case study.
Marty Siwak,
Director, Separations Sciences Group, JSR Life Sciences
Marty Siwak is director of the Separations Sciences Group at JSR Life Sciences. His team is responsible for purification process and product development technology. Mr. Siwak has developed and commercialized numerous separations and protein purification technologies over the past 35 years. He holds multiple patents and publications on protein purification and virus clearance technologies. He has degrees in both Chemical Engineering and Biochemistry from the University of Connecticut.
Guido Stroehlein,
Business Unit Manager, Bioprocess
Guido Stroehlein is the Business Unit Manager for JSR Life Sciences in Europe. Prior to joining JSR, Guido played a pivot role in co-founding and serving as CEO of ChromaCon AG, a company that provides novel chromatography processes and equipment for biologics. He has advanced degrees from Technical University Hamburg and the ETH Zurich including an MBA and Ph.D. in Chemical and Bioengineering. Guido co-authored more than 30 peer reviewed publications and holds several patents in continuous chromatography.
- Review and insight on establishing performance targets for the design of a protein A resin
- Resin design features and properties and how they relate to protein A performance
- Illustration of A3 Amsphere performance across several mAb types
- Principal Scientist Purification Process Development
- Senior Engineer Purification Development
- Vice President Bioprocess Development
- Senior Scientist and Senior Group Leader
- Purification Development
- Senior Scientist
- Scientist
- Associate Director Purification Development
